Ingredient Review - ActiGin
- 04 Jul, 2019
Introducing ActiGin®, NuLiv Science's proprietary sports nutraceutical comprised of two highly purified and fractionated extracts from Panax notoginseng and Rosa roxburghii by NuLiv’s pharmaceutical extraction and processing technology.
What can ActiGin do to help your performance
ActiGin® is the result of more than 10 years of research that has shown in one in-vivo and five human clinical trials to:
- Increase endurance time (time to exhaustion) in one high-intensity cycling exercise (80% VO2 max) by 20%*
- Increase energy (ATP) production by raising the pace-making enzyme Citrate synthase in the first step of the citric acid cycle by 42%*
- Speed up recovery by reducing inflammation in muscle as evidenced by the reduction of the inflammatory biomarkers TBARS (24%), MDA (44%), Interleukin 6 (IL-6) (35%), and Creatine kinase (CK) (69%)*
- Eliminate senescent muscle cells through macrophage phagocytosis in a fourth human clinical trial published in the Journal of Ginseng Research. Specifically, to decrease SA-β-gal and collagenase, reverse apoptotic DNA fragmentation and leukocyte infiltration, and increase iNOS and IL-6 mRNA expression in the quadriceps after 60-minute cycling at 70% VO2 max*
- Effectively facilitate senescent cell clearance in contracting muscles and helps maintain muscle stem cell numbers during exercise to enhance high-intensity endurance performance.*
Blood glucose is stored as glycogen in muscle. It is the fuel for the muscle to function during intense (anaerobic) exercise. Exercise induces inflammation on muscle membrane where insulin receptor and glucose transporter (GLUT4) are located and disrupts the supply of blood glucose into the muscle.
Pre-clinical and clinical trials suggest that ActiGin® preserves the insulin receptor and glucose transporter on muscle membrane during intensive exercise to ensure a continuous supply of blood glucose into the muscle for it to function properly.
This is supported by the reduced inflammation and increased glycogen buildup in muscle and also by the clearance of senescent muscle cell through macrophage phagocytosis in the latest human clinical trial published in the Journal of Ginseng Research.
How ActiGin® Works
One in-vivo and three human clinical trials on ActiGin® suggest that its effects on improving endurance/stamina, energy and recovery time in high-intensity exercises may be due to its ability to preserve insulin receptors and glucose transporters on muscle membrane during intensive exercises to ensure a continuous supply of blood glucose into the muscle.
Glucose is the fuel for muscle during intensive exercise. Depletion of glucose has detrimental effects on muscles to contract and work properly. There are senescent cells in all human tissues at certain proportions, particularly for those short-lived endothelial cells (lifespan < 2 weeks) in blood vessels of tissues. ActiGin® substantially reduced senescent cell population (mostly endothelial progenitor cells) of exercising skeletal muscle (Journal of Ginseng Research).
High-intensity exercise acutely decreases satellite cell numbers due to increased demand on nucleus for muscle regeneration during challenges. ActiGin® completely attenuated acute satellite cell depletion (Journal of Functional Foods).
These findings suggest that ActiGin® effectively facilitates senescent cell clearance in contracting muscles and helps maintain muscle stem cell numbers during exercise to enhance high-intensity endurance performance.*